Los carotenos y sus efectos sobre la salud
DOI:
https://doi.org/10.17533/udea.penh.336480Keywords:
B-carotenos, biodisponibilidad, cáncer, enfermedad cardiovascular.Abstract
El presente artículo es de revisión; en éste se examina la importancia de los p carotenos como fuente promisoria de provitamina A en los países menos desarrollados. Se consideran varios aspectos del huésped y del alimento que condicionan la biodisponibilidad de los p carotenos provenientes de la dieta, factores importantes a tener en cuenta cuando las fuentes de vitamina A son de origen vegetal. Igualmente, se analiza la efectividad de la suplementación de F3 carotenos en la protección del cáncer y las enfermedades cardiovasculares. Por último, se proponen algunas razones que justifican las discrepancias encontradas entre los estudios epidemiológicos, las observaciones sobre consumo de alimentos fuente de carotenos y los estudios aleatorios doble ciego con suplementos de p carotenos.Downloads
References
Olson JA. Carotenoids. En: Shills ME, Olson JA, Shike M, Ross AC. Modern nutrition in health and disease. Ed. Philadelphia: Williams and Wilkins, 1999. p.525-541
Olson JA. Vitamina A: conocimientos actuales sobre nutrición. 6 ed. Washington: OPS : ILSI; 1991. p. 113-135.
Bendich A. Conclusiones del simposio: acciones biológicas de los carotenos. Avan Nutr Diet 1989;3:5-6.
GroffJL, Gropper SS, Hunt S. Advanced nutrition and human metabolism. 2 ed. Minneapolis: West; 1995. p.284-297.
De Pee S, West CE. Dietary carotenoids and their role in combating vitamin A deficiency: a review of literature. Eur J Clin Nutr 1996; 50(Supp13):7S-12S.
Jalal FJ, Nesheim, MC, Agust Z, Sanjur D, Habich JP. Serum retinol concentrations in children are affected by food sources of b carotene, fat intake, and anthelmintic drug treatment. Am J Clin Nutr 1998;68:623-629.
Blomhoff R. Vitamin A and carotenoid toxicity. Food Nutr Bull 2001;22:320-334.
Silveira ER, Moreno FS. Natural retinoids and b-carotene: from food to their actions on gene expression. J Nutr Biochem 1998;9:446 456.
Arjan de Wagt. Vitamin A deficiency control programs in eastern and southern Africa: a UNICEF perspective. Food Nutr Bull 2001;22:352-356.
Codgia G. Food sources of vitamin A and provitamin A specific to Africa: an FAO perspective. Food Nutr Bull 200122:357-360.
Amoaful EF. Planning a national food-based strategy for sustainable control of vitamin A deficiency in Ghana: steps toward transition from supplementation. Food Nutr Bull 200122:361-365. vitamins and disease: prevention. Food Tech 1994;80-84.
Block G, Langseth L. Antioxidant vitamins and disease prevention. Food Tech 1994;48:80-84.
Stahelin HB, Gey KF, Eichholzer M, Judin E. Beta carotene and cancer prevention: the BASEL study. Am J Clin Nutr 1991; 53(suppi 1):265S-269S.
World Center Research Fund. American institute for Cancer Research. Food nutrition and the prevention of cancer: a global perspective. 1ed. Washington: Banta Book Group, 1997.
Auroma 01. Nutrition and health aspects of free radicals and antioxidants. Food Chem Toxic 994;32(7):671-683.
Bertram JS, Bortkiewcz H. Dietary carotenoids inhibit neoplastictransformation and modulate gene expression in mouse and human cells. Am J Clin Nutr 1995;62(suppl 6):1327S-1336S.
Herbert V. The antioxidant supplement myth. Am J Clin Nutr 1994;60:157-158.
Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Li B. The Linxian trials: mortality rates by vitamin mineral intervention group. Am J Clin Nutr 1995;62 (suppl 6):1424S-1426S.
The Alpha Tocopherol, Beta-Carotene cancer prevention study group. The effects of vitamin E and beta-carotene on the incidence of lung cancer and other cancer in male smokers. N Eng J Med 1994;330:1029-1035.
Omenn GS, Godman GE, Thornquist MD, Balmes J, Cullen MR, Glass A et al. Risk factor for lung cancer and for ntervention effects in CARET: the Beta carotene and retinol efficacy trial. J Nati Cancer lnst 1996;88:1550-1559,
Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Eng J Med 1996;334:1145-1149.
Greenberg ER, Baron JA, Stukel TA, Stevens MM. Mande! JS, Spencer SK, et al, A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The skin cancer prevention study group. N Engl J Med 1990;323:789-795.
Greenberg ER, Baron JA, Tosteson TD, Freeman DH, Beck GJ, Bond JH et al. A Clinical Trial of Antioxidant vitamins to prevent collateral adenoma. N Engl J Med 1994;331:141-147.
Cooper DA, Eldridge AL, Peters JC. Dietary carotenois and lung cancer: a review of recent research. Nutr Rev 1999;57:133-145.
Keaney JF. What is the scientific evidence for antioxidant therapy? En: 71st Scientific Sessions November 8-11, Dallas: 1998. www.amhrt.org. Consultado en febrero de 1999.
Tribble DL, Antioxidant consumption and risk of coronary heart disease: emphasis on vitamin C, vitamin E and eta carotene. A statement for healthcare professionals from American Heart Association. Circulation 1999;99:591-595.
Beecher GR. Phytonutrients' role in metabolism: effects on resistance todegenerative processes. Nutr Rey 1999;(Supp 2):3S-6S.
